hsp90 inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21883	Gedunin		HSP
	Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.		HSP
T8858	DTHIB		HSP
	DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.		HSP
T9202	DDO-5936		HSP
	DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.		HSP
T8958	PU-H54		GPR
	PU-H54 is a purine-based inhibitor of Grp94. It is a Grp94-selective resorcinol-based inhibitor isolated through probing of the exclusive binding region of S2 subpocket in Grp94.		GPR
T6442	CH5138303		HSP
	CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.		HSP
T6609	NMS-E973		HSP
	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.		HSP
T2258	VER-50589	VER50589	Apoptosis , HSP
	VER-50589 is a potent HSP90 inhibitor.		Apoptosis , HSP
T20890	Alvespimycin	17-DMAG,KOS1022,KOS 1022,KOS-1022	HSP
	Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.		HSP
T6343	Geldanamycin	NSC 122750	HSP , Influenza Virus , Tyrosine Kinases , Antibacterial , Antibiotic
	Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.
T3454	VER-49009	CCT 129397	HSP
	VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).		HSP
T27193	DN401	DN 401,DN-401	HSP
	DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.		HSP
T36123	3-Phenyltoxoflavin	ZINC267655,Phenyltoxoflavin	HSP
	3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.		HSP
T2268	VER49009	CCT0129397,VER 49009,VER-49009	HSP
	VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).		HSP
T6297	Alvespimycin hydrochloride	BMS 826476,NSC 707545,KOS-1022,17-DMAG hydrochloride,Alvespimycin (17-DMAG) HCl	Apoptosis , HSP
	Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.		Apoptosis , HSP
T6290	Tanespimycin	17-AAG,CP 127374,NSC 330507,KOS 953	Apoptosis , Mitophagy , HSP , Antibacterial , Antibiotic , Autophagy
	Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).
T6305	SNX2112	SNX-2112,PF 04928473,SNX 2112	HSP
	SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM.		HSP
T6960	PU-H71		HSP
	PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.		HSP
T4342	PF-04929113 Mesylate	PF-04929113 (Mesylate),SNX-5422 Mesylate	HSP , HER
	PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37 nM).		HSP , HER
T2286	BIIB021	BIIB 021,CNF2024,BIIB-021	HSP , Autophagy
	BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).		HSP , Autophagy
T2114	VER-82576	NVP-BEP800	HSP
	VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.		HSP